Crystallization, Separation, Extraction, and Quantification on a Microfluidic Platform

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dc.contributor.authorSingh, Sunil Kumar
dc.date.accessioned2024-05-01T09:26:36Z
dc.date.available2024-05-01T09:26:36Z
dc.date.issued2022
dc.descriptionSupervisor: Pattader Partho Sarathi Gooh
dc.description.abstractThe primary focus of the thesis is to explore, design and develop a microfluidic platform for the efficient resolution of enantiomers, surfactant separation, dye extraction, and Hemoglobin quantification. A flexible μ-reactor and a μ-crystallizer are fabricated for the continuous production of diastereomer salt crystals from racemic α-phenylethylamine (I) where optically active L-(+)-tartaric acid (II) is used as a resolving agent. Moreover, a Y-shape microchannel was fabricated and thin copper sheet electrodes were placed across the channel to separate both anionic and cationic surfactant simultaneously from its mixture under the influence of ultra-low electric voltage. It was found that separation efficiency solely depends on the residence time of the fluid. Furthermore, liquid-liquid extraction was investigated to transfer a component transfer from one liquid phase to another liquid phase under the presence of an applied external electric field in a microchannel. With this, we explored interfacial instability in the presence of an external electric field inside the microchannel for the extraction of methylene blue dye from the aqueous phase using N-amyl alcohol. Additionally, we attempt to develop a simple, low-cost, easy to use point of care (PoC) device based on the spectrophotometric principle for the quantification of Hemoglobin (Hb) on a microfluidic platform. The specific interactions of Methylene Blue (MB) with Hb in the presence of CDs show a unique characteristic optical feature, and the same is exploited for the quantitative estimation of Hb.
dc.identifier.otherROLL NO.156107038
dc.identifier.urihttps://gyan.iitg.ac.in/handle/123456789/2604
dc.language.isoen
dc.relation.ispartofseriesTH-2902
dc.titleCrystallization, Separation, Extraction, and Quantification on a Microfluidic Platform
dc.typeThesis
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