Studies on Superoxide Dismutase: An antioxidative protein from Cicer arietinum seedlings

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Superoxide dismutase is an important enzyme of the antioxidative defense system. It forms the first line of defense against reactive oxygen species and environment induced oxidative stress. Superoxide dismutase works in coordination with other antioxidative enzymes such as catalase, ascorbate peroxidase and glutathione peroxidase. These enzymes help in maintaining the ionic homeostasis, deplete the level of reactive oxygen species and subsequently limit the oxidative stress condition. Superoxide dismutase enzymes are classified based on their metal cofactor associated with the activity. Because of its high reactive oxygen species scavenging properties, it has numerous therapeutic applications. Recent advancement in the field of proteome research coupled with detailed reaction mechanism, in depth analysis of the crystal structure and in silico analysis suggests that superoxide dismutase is indispensible tool for numerous biological applications. However, search of a novel superoxide dismutase with unique properties is always of significant importance.
Supervisor: Vikash Kumar Dubey