Multifunctional nanomoaterials for theranostic applications

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Multifunctional nanomaterials have been a point of attraction in cancer research due to its breadth of applications in imaging, therapeutics and targeting. Apart from imparting targeted diagnosis and therapy, these systems render the advantages of combinatorial therapeutic regime in alleviation of cancer. Particularly, biopolymer based nanoparticle delivery systems have been developed for anticancer treatments, wound healing and hydrogel based injection modules. They can achieve efficient conjugation, entrapment, absorption and encapsulation of drugs or imaging probes and enable the delivery of the same to the desired regions. In addition, small chemical molecules also have been modified towards development of theranostic agents for enhancing therapeutic potential and cell permeability. Imaging techniques involved in field of theranostic is mostly dependent on various types of contrast agents out of which luminescence probes acquire special attention. Such luminescence based imaging probes can be used to monitor the accumulation of nanomaterials in tissues and to track their multivalent interactions in intracellular domain. This dissertation focusses on biopolymer as well as small molecule based multifunctional nanomaterials in achieving the combined goal of in vitro therapy and diagnostics in a single module.The chapter 1 begins with an insight into the fascinating world of multifunctional nanomaterials. It traces back to the developmental junctures of theranostic nano-medicine and discusses the most recent progresses in the field. Some of the landmark findings have been highlighted to convey the importance of multifunctional nanomaterials in different arenas.
Supervisors: Siddhartha Sankar Ghosh and Arun Chattopadhyay