Nanoparticles Based MIL-100(Fe) MoFs composites for Loading and Release of Doxorubicin Hydrochloride

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A drug delivery system (DDS) is defined as controlled release of- desired drugs to targeted location by responding to the external/environment stimulus. Porous materials based DDSs have got more attentions in recent times owing to their high surface area. large pore volume and tunable pore size. Metal organic frameworks (MoFs), a new class of porous material that are being widely investigated for drug delivery applications. In this work, iron based metal organic framework (MOF) MIL-100(Fe) and its composites with iron oxide (Fe3O4) Zinc oxide (ZnO) and Cerium Oxide (CeO2) nanoparticles (NP) were investigated as delivery agents for anticancer drug doxorubicin hydrochloride (DOX). A series of composited like Fe3O4 @MIL-100 ZnO@:MIL-100 and CeO2@MIL-100 were synthesized by adding different amount of nanoparticles to the solvent mixture used for synthesis of the MlL-100. The composites were further characterised by carious techniques like BET, TEM, FESEM, VSM (For magnetic particles) and TGA etc. It was observed that synthesis procedure of MIL-100 significantly affected its prorsity and thereby its drug loading capacityMIL-100 (Fe) prepared without HF as the mineralizing agent yielded MOF with higher mesoporosity and it has highest DOX loading capacity among pure MoFs (- 234 mg/g). In case of composites, synthesis using lower mesopores MOF, the inclusion of FE3O4 and ZnO nanoparticles enhance the mesopores and hence the drug loading capacity is increased by -75%. However. in case of Ceo2 in to the MOF structure charged the morphology of the nanoparticle into needle Iike structure. Therefore, no enhance in DoX loading capacity was observed possibly due to blocking of pores by particles. ln case of composites synthesis using high mesoporous MIL-100. inclusion of nanoparticle decreased the drug loading capacity. The inclusion of nanoparlicles in the mesopores possibly block its adsorption sites which resulted in a net decrease in DOX capacity
Supervisors: Mihir K Purkait and Sasidhar Gumnna