Biomineralisation and biomimetic materials chemistry: exploring the influence of crystal growth modifier

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The thesis entitled “Biomineralisation and Biomemetic Materials Chemistry: Exploring the influence of Crystal Growth Modifier” is divided into four chapters. Chapter:1 gives a brief introduction regarding background as well as literature survey of Biomineralisation. It describes how in nature, hard tissues in organism such as bone, teeth and mollusk shells, etc. forms and their characteristics. It also describes the literature survey of in vitro biomineralisation in presence of low as well as high molecular weight matrix. The various bioinorganic materials present in living systems are biominerals. e.g., Hydroxyapatite [Ca5(PO4)3(OH)], Calcite (CaCO3) etc. They are formed by all the living organisms starting from bacteria to higher plants and animals. It has shapes and sizes which are frequently different from analogous inorganic crystals. They are organized hierarchically and ordered at many length scales. Biominerals have very low solubility in the body fluid. Low solubility product of Ca salt is the main reason why it is the most abundantly found element in the naturally occurring biomineral. They are thermodynamically stable than the analogous inorganic crystals due to the consideration of the ionoic size, charge, packing, and their effect on hydration and lattice energies.
Supervisor: Gopal Das