Study of copper(II) based Oxidative C-H Functionalization/C-C/N-N/C-O Bonds Formation for synthesis of Substituted Azole

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The thesis contains four chapters. The first two chapters focus on the copper(II) based synthesis of 2-arylbenzoxazoles and 2-aryl-N-benzylbenzimidazoles from bisaryloxime ethers and N-benzylbisarylhydrazones via C functionalization/C bonds formation. The last two chapters deal with the copper(II)-catalyzed aerobic oxidative synthesis of substituted 1,2,3- and 1,2,4-triazoles from bisarylhydrazones via C bonds formation. 1. Synthesis of 2-Arylbenzoxazoles from Bisaryloxime Ethers via C Bonds Formation Benzoxazoles are an important class of heterocycles that are encountered in a number of biologically active natural products and medicinally significant compounds. This chapter describes an unprecedented copper(II)-catalyzed conversion of bisaryloxime ethers to 2- arylbenzoxazoles in presence of molecular oxygen at 80 ओC under ligand-free condition (Scheme 1). This process involves a cascade C functionalization/C bonds formation. The substrates bearing electron-withdrawing or electron-donating groups in the arenes proceeded reaction smoothly to provide the corresponding benzoxazoles in moderate to high yields..
Supervisor: T. Punniyamurthy