Exploration of Self-Assembly in Short Peptides for the Development of Useful Functional Materials
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Date
2022
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Abstract
The thesis on ‘Exploration of Self-Assembly in Short Peptides for the Development of Useful Functional Materials’ deals with the design of novel short peptides, studying their self assembly behaviour with the different non-covalent interactions, and exploring their possible applications in the field of peptide-based functional materials.
Chapter 1 is a brief introduction on peptide-based nanomaterials and their various
applications with sufficient literature review.
Chapter 2 describes the development of a thixotropic hydrogel using the self-aggregation of a peptide amphiphile.
Chapter 3 describes the successful utilization of the technique of peptide coassembly for the formulation of a functional peptide hydrogel for aiming localized drug-delivery through
receptor mediated cellular internalization mechanisms.
Chapter 4 deals in development of a multi-stimuli responsive cross-linked peptide polymer using different cross-linking methodologies, for attaining size-tunability property and controlled cell-proliferation.
Chapter 5 deals in development of an artificial hydrolase. The work involves systematic
design and immobilization of a hydrolase-like short peptide amphiphile on silica surfaces for enhancement of extent of catalysis, improvement of catalyst stability and increased stereoselectivity, compared to the micellar aggregates.
Description
Supervisor: Das, Debapratim
Keywords
Peptide, Self-Assembly, Hydrogel