Studies on identification and in vivo function of novel drug target enzymes of Leishmania donovani using biomolecular approaches

dc.contributor.authorBhardwaj, Ruchika
dc.date.accessioned2016-12-16T09:35:32Z
dc.date.accessioned2023-10-19T11:06:37Z
dc.date.available2016-12-16T09:35:32Z
dc.date.available2023-10-19T11:06:37Z
dc.date.issued2016
dc.descriptionSupervisor: Vikash Kumar Dubeyen_US
dc.description.abstractLeishmaniasis is a neglected parasitic disease caused by several species of Leishmania parasite. The current drug scenario against this disease is not very good, due to poor efficacy, high cost and major side effects. Moreover, there are several reports about resistance against available drugs. There is an eminent requirement for drugs with higher efficacy and lower side effects. Discovery and validation of novel drug targets are prerequisite for any drug discovery effort. In our study, we have chosen two proteins of the pathogen Leishmania, for evaluation as potential drug targets, viz. a conserved hypothetical protein and a functionally annotated protein, CAAX prenyl protease II. The conserved hypothetical protein, LdBPK_070020, was conserved throughout the other species of Leishmania hinting towards important role of the protein. The other possible target, functionally annotated protein CAAX prenyl protease II, has key role in Ras proteins maturation and localization. The sequence similarity of both the proteins with human genome was significantly low.en_US
dc.identifier.otherROLL NO. 126106002
dc.identifier.urihttps://gyan.iitg.ac.in/handle/123456789/770
dc.language.isoenen_US
dc.relation.ispartofseriesTH-1525;
dc.subjectBIOSCIENCES AND BIOENGINEERINGen_US
dc.titleStudies on identification and in vivo function of novel drug target enzymes of Leishmania donovani using biomolecular approachesen_US
dc.typeThesisen_US
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