Studies on identification and in vivo function of novel drug target enzymes of Leishmania donovani using biomolecular approaches
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Leishmaniasis is a neglected parasitic disease caused by several species of Leishmania parasite. The current drug scenario against this disease is not very good, due to poor efficacy, high cost and major side effects. Moreover, there are several reports about resistance against available drugs. There is an eminent requirement for drugs with higher efficacy and lower side effects. Discovery and validation of novel drug targets are prerequisite for any drug discovery effort. In our study, we have chosen two proteins of the pathogen Leishmania, for evaluation as potential drug targets, viz. a conserved hypothetical protein and a functionally annotated protein, CAAX prenyl protease II. The conserved hypothetical protein, LdBPK_070020, was conserved throughout the other species of Leishmania hinting towards important role of the protein. The other possible target, functionally annotated protein CAAX prenyl protease II, has key role in Ras proteins maturation and localization. The sequence similarity of both the proteins with human genome was significantly low.
Supervisor: Vikash Kumar Dubey
BIOSCIENCES AND BIOENGINEERING