Expeditious Thermal(Photo) Induced Functionalization/Annulation: En route to N-Heterocycles

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dc.contributor.authorKhandelia, Tamanna
dc.date.accessioned2024-05-29T11:43:22Z
dc.date.available2024-05-29T11:43:22Z
dc.date.issued2024
dc.descriptionSupervisor: Patel, Bhisma Kumar
dc.description.abstractThe content of the thesis has been divided into four chapters. The thesis streamlines the synthesis of aromatic and non-aromatic N-heterocycles. It contributes towards the facile formation of C−C, C−N, C−O and C−S bonds using o-alkynylanilines, maleimides, 2-aryl quinoxalines, (benz)imidazoles, boronic acids and disulfides. Chapter I introduces transition metal induced (thermal) and photochemical construction of C−C and C−Heteroatom bonds. The mechanism involved in both transition metal induced (thermal) and photochemical approach are discussed. Both the processes are explained in details with the help of suitable examples. Chapter II describes a Cu(I) mediated cascade cyclization/annulation of unprotected o-alkynylanilines with maleimides in one-pot. The protocol offers sequential formation of one C−N and two C−C bonds to deliver fused benzo[a]carbazoles having free NH skeletons. The annulated products have been exploited towards various applications. Chapter III describes a Cu(OTf)2 mediated regioselective de-aromatized aryl-hydroxylation across C(sp2)=N bond of 2-aryl quinoxalines and bis-N-arylation of (benz)imidazoles using aryl boronic acids. For dearomative aryl-hydroxylation, the C-center should be electrophilic (ca. 0.08), N-center nucleophilic (ca. −0.50), and the C(sp2)=N bond should be polarized (Δe = 0.609).
dc.identifier.otherROLL NO.186122116
dc.identifier.urihttps://gyan.iitg.ac.in/handle/123456789/2623
dc.language.isoen
dc.relation.ispartofseriesTH-3360
dc.titleExpeditious Thermal(Photo) Induced Functionalization/Annulation: En route to N-Heterocycles
dc.typeThesis
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