Development of ROS-responsive Turn-on Fluorogenic Prodrugs for the Delivery of Anti-inflammatory and Anti-cancer Drugs along with Hydrogen Sulfide

Abstract

My PhD thesis titled “Development of ROS-responsive Turn-on Fluorogenic Prodrugs for the Delivery of Anti-inflammatory and Anti-cancer Drugs along with Hydrogen Sulfide” comprises of five chapters. In chapter 1, the mechanism of reactive oxygen species (ROS) production and detoxification in biological systems have been highlighted. In addition, the development of ROS-responsive fluorogenic probes, non-fluorogenic anti-inflammatory and anti-cancer prodrugs, and fluorogenic anti-cancer prodrugs have been reviewed elaborately. Moreover, the biological function, detection techniques, and enzymatic production of H2S have been discussed briefly. Several synthetic donors of H2S such as hydrolysis-based, biothiol-triggered, ROS-responsive, and so on have been reviewed briefly.