Design, synthesis and study of photophysical/biophysical properties of small molecular scaffold peptides and fluorescent β-lactams

Simple item page
dc.contributor.authorYashmeen, Afsana
dc.date.accessioned2018-05-30T09:51:09Z
dc.date.accessioned2023-10-19T12:09:51Z
dc.date.available2018-05-30T09:51:09Z
dc.date.available2023-10-19T12:09:51Z
dc.date.issued2017
dc.descriptionSupervisor: Subhendu Sekhar Bagen_US
dc.description.abstractThis Thesis has a total of five chapters out of which the Chapter 1 is a literature review about the β-hairpin and β-sheet peptidomimetics. This review chapter contains a critical survey of conformationally constrained small molecular scaffold as inducer of particular secondary structure in a peptide, such as β-hairpin and β-sheet peptidomimetics. Chapter 2 includes uracil-di-aza-amino acid (UrAA) as a new family of molecular scaffold with ability to induce β-hairpin structure with H-bonded β-sheet conformation in a short peptide which is demostrated in two designed fluorescent pentapeptides. We established the dual mechanism of exciplex emission in ExcipFRET-peptide 2.61 containing donor-acceptor triazolyl unnatural fluorescent amino acids TMnapAlaDo and TPyAlaDo at N- and C- terminus respectively, forming a FRET pair. On the other hand fluorescent pentapeptide Excim-peptide 2.64 with triazolyl fluorescent unnatural amino acid TPyAlaDo at both the termini showed excimer emission in its β-sheet conformation. Both the peptides maintainning their predefined photophysics were found to interact with a model biomolecule BSA with fluorescence swith-on response. The exploration of sequence specific DNA binding event of UrAA scaffold and study of interaction with other protein biomolecules is the future prospect of this work.en_US
dc.identifier.otherROLL NO.11612202
dc.identifier.urihttps://gyan.iitg.ac.in/handle/123456789/962
dc.language.isoenen_US
dc.relation.ispartofseriesTH-1707;
dc.subjectCHEMISTRYen_US
dc.titleDesign, synthesis and study of photophysical/biophysical properties of small molecular scaffold peptides and fluorescent β-lactamsen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
Abstract-TH-1707_11612202.pdf
Size:
402.63 KB
Format:
Adobe Portable Document Format
Description:
Abstract
Download
No Thumbnail Available
Name:
TH-1707_11612202.pdf
Size:
30.65 MB
Format:
Adobe Portable Document Format
Description:
Thesis
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download
Collections
PhD Theses (Chemistry)