Cucurbit[8]uril Assisted Vesicle Formation by Viologen Amphiphiles: A Systematic Analysis and Application

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This thesis entitled “Cucurbit[8]uril Assisted Vesicle Formation by Viologen Amphiphiles: A Systematic Analysis and Application” deals primarily with supramolecular host-guest chemistry based on Cucurbit[8]uril. The research has been focused on the understanding of self-assembly of viologen amphiphiles in absence and presence of Cucurbit[8]uril and construction of stimuli sensitive self-assembled system. Chapter 1 is a brief introduction to the Cucurbituril host family, its discovery, synthesis and host-guest interaction with viologen amphiphiles, an up to date review on this field along with brief introduction to the present thesis. Chapter 2 describes the different physicochemical parameters of a viologen surfactant DDEV in pure and mixed state with three tetraalkylammonium bromide surfactants. The molar ratio varied from 0-100% and we found that doping of 1% DDEV does not imparts any change in the physicochemical parameters of Tetraalkylammonium bromide surfactants. Chapter 3 is the extension of previous chapter. Here we have shown how Mutual Sharing of Properties of Individual Surfactants in the 1% DDEV Doped Systems occurs to construct vesicle and w/o-microemulsion which is not possible in absence of one. Chapter 4 describes the mechanism of micelle to vesicle transformation by viologen amphiphiles in presence of Cucurbit[8]uril and DHN. In this chapter we have also shown two types of self-sorting parallely occurs during the transformation. Chapter 5 describes the vesicle formation ability of different amino acids in presence of Cucurbit[8]uril and DHN. We have developed supramolecular peptide amphiphile which eventually transformed to vesicle. Lastly we have shown its multi-stimuli responsiveness.
Supervisor: Debapratim Das