Transition Metal Catalyzed C-H Functionalization: Construction of C-C, C-O and C-X Bonds

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dc.contributor.authorSantra, Sourav Kumar
dc.date.accessioned2017-11-27T10:31:14Z
dc.date.accessioned2023-10-19T12:09:47Z
dc.date.available2017-11-27T10:31:14Z
dc.date.available2023-10-19T12:09:47Z
dc.date.issued2016
dc.descriptionSupervisor: Bhisma Kumar Patelen_US
dc.description.abstractCross-coupling reactions are widely used in both industry and academia for the installation of functional group and untied a new gate in organic synthesis. However, now-a-days CH functionalization strategies have received significant attention from the atom economy point of view. In this context two fundamental approaches viz. ligand directed CH functionalization and cross-dehydrogenative coupling (CDC) are the most preferred synthetic protocols. The thesis work based on the development of directing group assisted site selective C−H activation protocols to generate caraboncarabon (C−C) and carbonheteroatom (C−X) bonds. Two privileged motifs present in many naturally occurring molecules such as benzothiazoles and quinoxalines were used for ortho-selective aroylation, carboxylation and halogenations. For o-aroylation and o-carboxylation both 2,3 diarylquinoxalines and 2-arylbenzothiazoles provided mono-o-functionalized product whereas for o-halogenation of 2-arylbenzothiazoles afforded di halogenated product which is quite different from usual reports. The thesis work also consists of non activated keto amide sp3 C−H functionalization in the presence of Pd(II)/Cu(II) combination. Apart from these work, a ,-sp3 C−H functionalization strategy of tertiary amines was also developed for the cycloaddition reaction.en_US
dc.identifier.otherROLL NO.11612205
dc.identifier.urihttps://gyan.iitg.ac.in/handle/123456789/865
dc.language.isoenen_US
dc.relation.ispartofseriesTH-1617;
dc.subjectCHEMISTRYen_US
dc.titleTransition Metal Catalyzed C-H Functionalization: Construction of C-C, C-O and C-X Bondsen_US
dc.typeThesisen_US
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