Site-Selective C-H Functionalization of Indoles: Studies towards C-C and C-N Bond Formation
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Date
2024
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Abstract
The thesis is structured into four chapters. The first chapter describes a Ru-catalyzed regioselective C-N bond formation of indolines and carbazole with acyl azides via C7(sp2)-H activation followed by an intramolecular C-N bond formation for the construction of 7- aminoindoline and 1-aminocarbazole scaffolds. The second chapter deals with Cu-catalyzed C7- selective C-H/N-H cross-dehydrogenative coupling of indolines and azaindoles with sulfoximines. The third chapter demonstrates a Rh-catalyzed site-selective C7 and C6 dual C-H functionalization of indolines expending 7-azabenzonorbornaiene for the formation of functionalized pyrrolocarbazoles. The fourth chapter focuses on Pd-catalyzed weak-coordination facilitated C4- selective redox-neutral nitration of indoles with tert-butyl nitrite under aerobic oxidation catalysis.
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Supervisor: Punniyamurthy, T
Keywords
Indole Functionalization, Carbazole, Sulfoximine, C7-Amidation, C7-Amination, C7 and C6-Dual Functionalization, Pyrrolocarbazole formation, C4-Nitration, Mechanistic Investigations, Broad Substrate Scope, Post-synthetic Utilities