Studies Toward Chelation Assisted Ortho-Selective C-H Bond Functionalization of Arenes
| dc.contributor.author | Sadhu, Pradeep | |
| dc.date.accessioned | 2017-05-09T09:51:09Z | |
| dc.date.accessioned | 2023-10-19T12:09:31Z | |
| dc.date.available | 2017-05-09T09:51:09Z | |
| dc.date.available | 2023-10-19T12:09:31Z | |
| dc.date.issued | 2016 | |
| dc.description | Supervisor: T Punniyamurthy | en_US |
| dc.description.abstract | The chapter 1 describes the literature survey of the transition-metal-catalyzed cross-coupling, C-H activation, chelation-assisted C-H functionalization and their mechanisms. Chapter 2 demonstrates Pd-catalyzed ortho-halogenation of N-aryl ring of N,1-diphenyl-1H-tetrazol-5-amines via chelation assisted C-H functionalization utilizing N-halo succinimide (NXS) as halogen source and CF3SO3H as an additive at moderate temperature. Chapter 3, presents a room temperature Cu-catalyzed chemo- and regioselective nitration of arenes using Fe(NO3)3∙9H2O as a nitro source. Here, 5-aminotetrazole and 3-amino-1,2,4-triazoles serve as the chelating groups. The directing group can be cleaved to give 2-nitroanilines in good yields. The mechanistic aspects have been illustrated based on kinetic isotope studies, ESI-MS and radical scavenger experiments. Chapter 4, focuses on Cu-mediated regio-selective cross-dehydrogenative coupling (CDC) approach for the N-arylation of azoles under basic conditions. The reaction of pyrroles, indoles, pyrazoles and carbazole has been included. The kinetic studies show that the C-H bond cleavage takes place in the rate determining step. | en_US |
| dc.identifier.other | ROLL NO.11612209 | |
| dc.identifier.uri | https://gyan.iitg.ac.in/handle/123456789/809 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartofseries | TH-1564; | |
| dc.subject | CHEMISTRY | en_US |
| dc.title | Studies Toward Chelation Assisted Ortho-Selective C-H Bond Functionalization of Arenes | en_US |
| dc.type | Thesis | en_US |
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