Newer Strategies for the synthesis of Heterocycles Using Thiophilic Reagents
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The contents of this thesis have been divided into six chapters based on the results of experimental works performed during the complete course of the research period. The introductory chapter of the thesis presents an overview of various thiophilic reagents, heterocumulenes and their importance in the synthesis of heterocycles. Chapter-II describes the preparation of isothiocyanate, cyanamide and thiazole through desulfurization of dithiocarbamic acid salt with ditribromide reagent 1,1'-(ethane-1, 2-diyl) dipyridinium bistribromide (EDPBT). Chapter-III demonstrates the syntheses of five and six membered N, O, S heterocycles again using EDPBT. Chapter-IV illustrates the detailed mechanistic investigation of anti-Hugerschoff reaction. Chapter-V and VI mainly focus on the synthesis of tetrazoles, thiadiazoles and 2-imino-4-thiazolidinones using molecular iodine and chloroacetylchloride. Each chapter consists of four sub sections, describing introduction, present work, experimental work and spectral data respectively.....
Supervisor: Bhisma K. Patel and Mihir K Chaudhuri