Development of ortho-nosylOXY as a novel coupling reagent for peptide synthesis and related organic transformations
| dc.contributor.author | Dev, Dharm | |
| dc.date.accessioned | 2018-05-30T09:39:27Z | |
| dc.date.accessioned | 2023-10-19T12:09:53Z | |
| dc.date.available | 2018-05-30T09:39:27Z | |
| dc.date.available | 2023-10-19T12:09:53Z | |
| dc.date.issued | 2016 | |
| dc.description | Supervisor: Bhubaneswar Mandal | en_US |
| dc.description.abstract | We developed a reagent coupling reagent ethyl 2-cyano-2-(2-nitrobenzenesulfonyloxyimino)acetate (ortho-NosylOXY) and its application for the synthesis of amides, esters, peptides, hydroxamates, N-protected amino acid based benzoxazoles & benzothiazoles and nitriles. The whole structure of the thesis is depicted in scheme 1. Firstly, we have developed a method for the synthesis of o-NosylOXY and its application for racemization free synthesis of amides and peptides. Secondly, we established a method for racemization free synthesis of ester and hydroxamates using o-NosylOXY. Thirdly, we illustrated synthesis of benzoxazole and benzothiazole from carboxylic acid and N-protected amino acid by o-NosylOXY. Fourthly, we demonstrated the application of o-NosylOXY for nitrile synthesis. Finally, we described the synthesis of amide/lactam from ketoxime via Beckmann rearrangement and o-NosylOXY as a organocatalyst. | en_US |
| dc.identifier.other | ROLL NO.11612240 | |
| dc.identifier.uri | https://gyan.iitg.ac.in/handle/123456789/961 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartofseries | TH-1706; | |
| dc.subject | CHEMISTRY | en_US |
| dc.title | Development of ortho-nosylOXY as a novel coupling reagent for peptide synthesis and related organic transformations | en_US |
| dc.type | Thesis | en_US |
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