Development of ortho-nosylOXY as a novel coupling reagent for peptide synthesis and related organic transformations

dc.contributor.authorDev, Dharm
dc.date.accessioned2018-05-30T09:39:27Z
dc.date.accessioned2023-10-19T12:09:53Z
dc.date.available2018-05-30T09:39:27Z
dc.date.available2023-10-19T12:09:53Z
dc.date.issued2016
dc.descriptionSupervisor: Bhubaneswar Mandalen_US
dc.description.abstractWe developed a reagent coupling reagent ethyl 2-cyano-2-(2-nitrobenzenesulfonyloxyimino)acetate (ortho-NosylOXY) and its application for the synthesis of amides, esters, peptides, hydroxamates, N-protected amino acid based benzoxazoles & benzothiazoles and nitriles. The whole structure of the thesis is depicted in scheme 1. Firstly, we have developed a method for the synthesis of o-NosylOXY and its application for racemization free synthesis of amides and peptides. Secondly, we established a method for racemization free synthesis of ester and hydroxamates using o-NosylOXY. Thirdly, we illustrated synthesis of benzoxazole and benzothiazole from carboxylic acid and N-protected amino acid by o-NosylOXY. Fourthly, we demonstrated the application of o-NosylOXY for nitrile synthesis. Finally, we described the synthesis of amide/lactam from ketoxime via Beckmann rearrangement and o-NosylOXY as a organocatalyst.en_US
dc.identifier.otherROLL NO.11612240
dc.identifier.urihttps://gyan.iitg.ac.in/handle/123456789/961
dc.language.isoenen_US
dc.relation.ispartofseriesTH-1706;
dc.subjectCHEMISTRYen_US
dc.titleDevelopment of ortho-nosylOXY as a novel coupling reagent for peptide synthesis and related organic transformationsen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
Abstract-TH-1706_11612240.pdf
Size:
309.09 KB
Format:
Adobe Portable Document Format
Description:
Abstract
No Thumbnail Available
Name:
TH-1706_11612240.pdf
Size:
18.69 MB
Format:
Adobe Portable Document Format
Description:
Thesis
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description: