Effect of Pyridine and Imidazole Functionality on Chiral Resolution, Solution Spin State and Electrochemistry within Ni (II) and Fe (II) Complexes

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This thesis work stems from our quest to find a simple way to recognize an enantiomer from a racemic mixture using coordination bond. To do that, we choose to use Ni (II)(high-spin) and Fe (II) (low-spin) complexes of chiral bidentate Schiff-base ligands. Observations on Fe (II) complexes led to finding complexes that show high- spin <--> low-spin transitions in solution. Digging deeper with more complexes along with a host of electrochemical and spectrometric tools, we ended up finding an intimate relationship between donor groups, redox potential, and spin-state. The effect of replacing pyridine with imidazole on redox and the spin-state properties discussed in the thesis is relevant to biomimetic chemistry. Imidazole group is a part of L- histidine amino acid, ubiquitous in metalloenzyme active sites. On the other hand, pyridine donor is typical in ligands related to biomimetic chemistry.
Supervisor: Ray, Manabendra
Pyridine and Imidazole Functionality, Chiral Resolution, Solution Spin-state, Electrochemistry, Ni(II) High-spin and Fe(II) Low-spin Complex, Spin-crossover