Development of Silk Fibroin Based Scaffolds for Tissue Engineering and Regenerative Medicine

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(Abstract not available with the Thesis)}:SYNOPSIS: The chronic shortage of donor transplants coupled with high morbidity and mortality without transplantation, and limitations associated with other conventional therapies has spurred the development of tissue engineering (TE) and regenerative medicine (RM) as a potential alternative therapy for tissue and organ failure. However the design and fabrication of an artificial extracellular matrix, with appropriate composition and configuration, for optimal cell response is one of the critical and challenging technological barriers, for which scaffold engineering has become a prime focus of research within the field of TE. With respect to composition, several biomaterials have been tested for their suitability in TE, amongst which silkworm silk fibroin has gained widespread attention owing to its unusual mechanical strength, biocompatibility, biodegradability and amenability to aqueous and organic processing. However, fibroin from nonmulberry sources, despite its superior qualities over its counterpart, has not been explored in great deal. With respect to scaffold configuration, amongst several fabrication techniques, fiber bonding and textile based methods have gained increasing consideration as they promise to yield a nonwoven fibrous, both of micro-nanoscale, structures that resemble native extracellular matrix..
Supervisor: Utpal Bora