Fabrication of Novel Hydrogel Films for Drug Delivery Applications: Influence of Crosslinker and Nanomaterials on Film Properties
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Date
2020
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Abstract
The potential applications of hydrogels, which made up of NaCMC (sodium
carboxymethylcellulose), HPMC (hydroxypropylmethylcellulose) and citric acid (CA), have
been investigated for wound healing and drug delivery applications in the current work.
Significances of findings are: (a) the hydrogel films of NaCMC-HPMC/20% CA are loaded with cationic drug (methylene blue) and the loading efficiency is significantly (approximately 23 times) higher than previous reports. (b) first time, zinc oxide complex of less than 50 nm is synthesized on hydrogel films for wound healing applications. (c) the hydrogel films of NaCMCHPMC- CuO/20% CA containing spherical nanoparticles of approximately 2-4 nm of Cu and 5- 10 nm of Cu2O are fabricated for wound healing applications. (d) first time, micellar nanoparticles are synthesized from NaCMC and grapefruit seed extract (GFSE) with a size of 50-90 nm. (e) the elongation at break (%) of NaCMC-HPMC-ZnO/1% GFSE hydrogel films is significantly higher than previous reports.
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Supervisor: R. Anandalakshmi
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CHEMICAL ENGINEERING