Development of Inhibitors for Immunosuppressive Indoleamine 2,3- dioxygenase 1 Enzyme

Abstract

This thesis titled as “Development of Inhibitors for Immunosuppressive Indoleamine 2,3-dioxygenase 1 Enzyme” focused on developing small molecule for robust and selective inhibition of IDO1. We have explored the therapeutic potential of our synthesised inhibitors for the immunotherapeutic treatment of various diseases, especially cancer. We also induced photopharmacology by synthesizing stimuli sensitive prodrugs. The entire work is arranged into four chapters as mentioned below.