Development of Novel Recyclable Coupling Reagents and Investigation on Chirality Controlled Self-Assembly of Dipeptides

Abstract

This thesis contributes to the development of novel coupling reagents for sustainable organic transformations. We demonstrated straightforward, efficient methods for synthesizing these coupling reagents. These reagents demonstrate excellent stability and are easily scalable. They are efficient for synthesizing racemization-free amides, hydroxamates, esters, thioesters, and peptides sustainably. Additionally, they are effective in modifying natural products and drug molecules under optimized conditions and synthesizing bioactive long-chain linear and cyclic peptides in solid-phase using green solvent mixtures. Some of our coupling reagents are also effective in synthesizing nitriles and assist in the metal-catalyzed synthesis of ketones from carboxylic acids with excellent yields. We synthesized a diverse library of amides, hydroxamates, esters, thioesters, peptides, nitriles, and ketones with excellent yields.