Lakshminath Bezbaroa Central Library Digital Repository
Welcome to the Institutional Digital Repository of Lakshminath Bezbaroa Central Library.
- This digital archive comprised of the Institutes' intellectual output.
- It manages, preserves & makes available the academic works of faculty and research scholars.
- It is established to facilitate deposit of digital content of scholarly or heritage nature.
- Allowing academics & their departments to share & preserve contents in a managed environment.
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Recent Submissions
Relativistic Accretion Flows Around Rotating Black Holes: Effects of Viscosity, Thermal Conduction, and Magnetic Fields
(2025) Singh, Monu
The comprehensive analysis presented in this thesis significantly advances the understanding of the physics governing relativistic accretion flows onto black holes. This thesis investigates hot, relativistic, viscous, and magnetized accretion flows around rotating black holes, focusing on how viscosity, thermal, conduction, and magnetic fields governs the flow properties, controlling the thermodynamics and radiative signatures of accreting black hole systems. The transonic properties of the flow are regulated by the by the radially varying viscosity, and modifies the critical points. Thermal conduction transfers the heat from the inner region of the flow to the outer region and thermodynamics properties of the flow gets altered and hence the luminosity and spectral energy distribution. Furthermore, magnetic field plays a vital role in transport of the angular momentum and synchrotron emission process. Overall, the thesis presents a framework for understanding the various aspects of relativistic accretion flows.
Investigating the intrinsic photophysical properties and potential anticancer activity of compound DHF from Alpinia nigra
(2024) Boro, Heeramoni
The plant Alpinia nigra, known for its medicinal value, yields 3,5-dihydroxy-7,4’-dimethoxyflavone (DHF), a non-polar compound poorly soluble in water. However, DHF's limited solubility in water necessitated investigations into enhancing its aqueous solubility. Through UV-visible studies, DHF's solubility across various pH levels was explored, revealing highest solubility at pH 13, accompanied by a notable red shift in absorption peak. Furthermore, interactions between DHF and Hen Egg White Lysozyme (HEWL) aggregates at different pH conditions were examined, highlighting DHF's ability to inhibit fibril formation, particularly in acidic (pH 2) environments. However, it is noteworthy that DHF's inhibitory influence is not extended to amorphous aggregates at pH 5. Conversely, under the distinctly alkaline conditions at pH 12.2, DHF's inhibitory impact on HEWL aggregates is of a milder nature. In the context of cancer research, DHF demonstrated significant inhibition of colon cancer cell migration and proliferation, without cytotoxic effects on normal cells. DHF's non-cytotoxicity in normal HaCaT cells distinguishes it, highlighting its potential as an anticancer agent. In cancer cells SW480 and HCT116, DHF exhibits significant inhibition of proliferation and migration, upregulating E-cadherin and downregulating N-cadherin and CXCR4 expressions. Comparative analysis with kaempferol, a structurally related compound known for its anticancer properties, underscored DHF's efficacy in inhibiting cell proliferation. These findings advocate for further exploration of flavonoids, like DHF, as promising candidates in cancer therapy, emphasizing the importance of harnessing natural compounds for combating cancer. Overall, this multifaceted investigation sheds light on DHF's diverse pharmacological potentials, from enhancing solubility to impeding amyloid aggregation and inhibiting cancer cell proliferation, thus opening new avenues for therapeutic interventions.
Numerical Investigations of Incompressible Buoyancy-driven Flows over Wide Parametric Ranges using Lattice Boltzmann Method
(2024) Bhuyan, Shikha
This thesis presents a comprehensive exploration of the Lattice Boltzmann Method (LBM) applied to buoyancy-driven flow in a single fluid phase. Using the D2Q9 lattice and the LBGK method in two dimensions, the developed LBM codes showcase remarkable performance across diverse problem sets. Rigorous validation exercises ensure the accuracy and realism of parameterizations. The research begins with validations through simulations of benchmark isothermal and thermal flow problems, followed by the application of the thermal lattice Boltzmann method (TLBM) to study natural convection, including non-Boussinesq simulations.
Aspects of Inflationary Magnetogenesis
(2025) Pal, Sourav
This thesis investigates how inflation can generate primordial large-scale magnetic fields and imprint quantum signatures on them and on gravitational waves. It develops: (i) an EFT framework that breaks conformal invariance while avoiding strong coupling and backreaction, with reheating-driven amplification; (ii) an anisotropic (Bianchi I) mechanism yielding viable present-day fields; and (iii) quantum-information tools using squeezed states and Stokes operators to test the quantum origin of these primordial fields.
Study on Caseinolytic Protease Chaperones and its Cognate Adaptors of Leptospira Interrogans
(2025) Kumari, Surbhi
Bacterial Caseinolytic protease (Clp) systems are central to protein quality control, mediating the ATP-dependent degradation of misfolded or aggregated proteins. In Leptospira interrogans, the Clp machinery comprises two proteolytic isoforms (ClpP1 and ClpP2), multiple ATPase chaperones (ClpA, ClpC, ClpX), and adaptor proteins (ClpS1, ClpS2). The core protease forms a hetero-tetradecameric ClpP1P2 complex that exhibits intrinsic peptidase activity toward short peptides, while degradation of protein substrates requires association with ATPase chaperones such as ClpX. However, the structural basis for selective activation and regulation of leptospiral Clp components remains poorly understood.