Lakshminath Bezbaroa Central Library Digital Repository
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Recent Submissions
Photo and Electrochemical Strategies to C-N Bond Formation
(2024) Alam, Tipu
The contents of this thesis have been divided into six chapters based on the experimental works performed and results obtained during the research period. The introductory chapter of the thesis represents a summary of ‘Photo and Electrochemical Strategies to CN Bond Formation’. For simplicity and brevity, Chapter I is divided into two parts. Chapter IA includes a photochemical CN bond formation via difunctionalization of alkenes and indoles, whereas, Chapter IB deals with electrochemical approach for the CN bond construction. The subsections of Chapter IA and IB are based on the mode of reactivity of difunctionalization and cross-coupling reactions.
Role of Multiple Reminders on Prospective Memory Performance Across Varied Interference Scenarios
(2024) Ojha, Pallavi
A famous saying suggests "more the merrier". The present thesis is built around the central premise of the quote. We tested volunteers' performance on future tasks involving prospective memory cued through specific events and future time. Results suggest that, in general, two cues improve future task performance. We tested future memory performance across varying levels of attention and cognitive load, variables that can modulate the memorability of cues on future learning tasks. While attention moderately influences performance, cognitive load majorly influences future task performance. We conducted experiments to test whether the benefit of multiple cues on future task performance holds over intervals filled with restful naps. We found that naps do not beneficially modulate the relationship. Overall, the results of the thesis suggest that "more the merrier" does hold in terms of prospective memory. Still, many constraints guide the relationship as it happens in real-world relationships
Self-assemblies of Sulphonamide Derived Urea, Thiourea and Conformational Isomers of a Mercury complex
(2024) Nath, Jitendra
The thesis described various solid-state assemblies of urea and thiourea derivatives of sulfa-drugs that had sulphonamide functional group as part of the structural backbone. The hydrogen bonded assemblies of these compounds, solvates, and polymorphic solvates were structurally characterized. The role of dimeric hydrogen bonded moieties within those self-assemblies to modulate the number of solvent molecules in solvates and also providing an aid to understand polymorphs were discussed. A theoretical calculation on dimeric hydrogen bonded assemblies could establish the observed trends in the melting points in a series of positional isomeric compounds. The utilities of these thiourea or urea-based compounds to encapsulate tetrabutylammonium halides, and also in the detection of fluoride ions in solution were described in the thesis. The content had descriptions on the conformational isomers of a mercury complex involving a thiourea based compound linked to an anthracenyl unit where distinctions of the isomers in solution as well as in solid states could be possible. The conformational changes observed from experimental studies were also complemented by theoretical energy optimizations to provide insights to the structure-property relationships
Understanding the role of alpha-synuclein in Japanese encephalitis virus replication and evaluation of pyrazole derivatives as therapeutics against its infection
(2024) Gupta, Anjali
In the prognosis of Japanese encephalitis virus (JEV) infection, many host factors have been identified as being involved in the various steps of the viral life cycle. Since it is a neurotropic virus, understanding the role of neuronal-specific proteins and local cellular homeostasis in developing therapeutics against JEV is an active area of research. Alpha-synuclein (α-syn) is one of the neuronal-specific proteins regulating synaptic plasticity and has been reported to have antiviral potential in related neurotropic viruses. JEV-infected patients displaying Parkinson's disease (PD)-like symptoms have been reported to have α-syn overexpression in the brain regions. As per reports, phosphorylation at S129 position plays a major role in aggregation and α-synucleinopathy. Therefore, exploring the function of α-syn in JEV induced death of dopaminergic neurons and α-synucleinopathy is essential. To this day, the present study reports the functional role of α-syn in JEV pathogenesis as well as explores the anti-JEV therapeutic candidates. There is a significant increase in endogenous α-syn expression during JEV replication, demonstrating a substantial reduction in JEV replication, suggesting an anti-JEV effect. α-syn was found to modulate the anti-oxidative pathway by increasing the expression of superoxide dismutase 1 (SOD1). The pathological implications of α-syn phosphorylation were carried out by studying casein kinase 2 (CK2) and Polo-like kinase (PLK2) involved in α-syn phosphorylation. Detailed analyses of CK2 and PLK2 reveal a notable reduction in these kinases, particularly during the late phase of JEV replication, thereby reducing the phosphorylated α-syn (pα-synS129) protein level. The intracellular α-syn oligomerization was increased in JEV-infected cells. Pyrazole derivatives with anti-oxidative properties were found to have anti-JEV activity. Comprehensive in vitro and in vivo studies showed compounds suppressed JEV-induced reactive oxygen species (ROS) generation through NRF2-SQSTM1 signaling mechanisms. This study contributes valuable insights into the interplay between α-syn and JEV, shedding light on avenues to study further the potential role of α-syn aggregation in JEV pathogenesis and exploit it to develop broad-spectrum antiviral therapeutics.
Search for New Physics at the future Lepton Coliders
(2024) Jahedi, Sahabub
The Standard Model (SM) of particle physics has successfully explained the fundamental forces of nature and was solidified with the discovery of the Higgs boson. However, various theoretical and experimental motivations drive us to explore beyond the SM (BSM). Statistical analysis plays a crucial role in this exploration, applied to different collider experiments to search for different BSM scenarios. Chapter 1 of the thesis introduces the SM particle spectrum, its limitations, and discusses approaches to address these limitations. It also outlines the outlook for past, present, and future colliders, focusing on lepton colliders. Chapter 2 delves into two statistical techniques: binned analysis and the optimal observable technique (OOT). Chapter 3 explores OOT in a BSM-dominated scenario, particularly in estimating Z boson couplings at e+e- collider and studying dark matter phenomenology. Chapter 4 shifts focus to scenarios where the SM
dominates, investigating the determination of anomalous neutral triple gauge couplings (nTGCs) through diboson
production and dimension-6 effective couplings through top-quark pair production at the e+e- collider. Chapter 5 examines experimental constraints on dimension-6 four-Fermi SMEFT operators and explores flavor probes through flavor-changing top-charm production at the muon collider. Chapter 6 studies optimal sensitivity of NP couplings in the presence of SM background using numerical techniques. Finally, Chapter 7 provides a summary of the thesis and suggests potential future directions