Kumar, Karan2025-03-112025-03-112024ROLL NO.186151015https://gyan.iitg.ac.in/handle/123456789/2830Supervisors: Moholkar, Vijayanand S and Barbora, LepakshiThis thesis presents a comprehensive scientific investigation focusing on the challenges and advancements in bioalcohol (mainly biobutanol) synthesis through Clostridia , emphasizing enhancing production efficiency from sustainable resources. Emp loying a multidisciplinary approach, the research encompasses comparative genomic analysis, in depth exploration of cell central metabolism during ABE fermentation, experimental examination of butanol production from lignocellulosic hydrolysates using Clos tridial co culture systems, development of genome scale metabolic models (GSMs), and innovative investigations into production of value added bioalcohol using sono enzymatic processes.enThesis