Synthesis of Nitrogenous Heterocycles via Multicomponent Reaction and Exploration of Naphthalen-2-ol Sulfides to Access Benzylic Ethers & Naphthofurans
No Thumbnail Available
Date
2016
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The contents of this thesis entitled “Synthesis of Nitrogenous Heterocycles via Multicomponent Reaction and Exploration of Naphthalen-2-ol Sulfides to Access Benzylic Ethers & Naphthofurans”. Multicomponent reactions are elegant process for the synthesis of various six member nitrogen containing organic frameworks. Different approaches have been developed and applied to construct a wide collection of these heterocyclic moieties. The first four chapter contains an introduction and nitrogenous heterocycles synthesis.using MCR approaches. Chapter I focuses on the synthesis of an important class of nitrogen heterocycles, 1,4-dihydropyridine found in numerous synthetic pharmaceutical agents. This chapter shows synthesis of 5,6-unsubstituted 1,4-dihydropyridine derivatives through one pot three-component reaction from ?,?-unsaturated aldehydes, amines and 1,3-diketones in methanol at room temperature using hydrated ferric sulfate as recyclable catalyst. In Chapter III explore of our synthesized C5-C6-unsubstituted 1,4-dihydropyridines for the construction of exo-hexahydro-1H-chromeno[3,4-h][1,6] naphthyridine-3-carboxylates via stereoselective Povarov reaction using 3-aminocoumarins, aldehydes and 5,6-unsubstituted 1,4-dihydropyridine derivatives employing 10 mol% of Yb(OTf)3.
Description
Supervisor:Abu T. Khan and Mohammad Qureshi
Keywords
CHEMISTRY