Synthesis of five- and six-membered nitrogen and sulfur heterocyclic compounds

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Date
2018
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Abstract
The content of this thesis has been divided into five chapters based on the results of experiment work performed during the complete course of the research period. The chapter 1 of the thesis presents an introduction to nitrogen and sulfur heterocyclic compounds, their biological significance and the literature method for their synthesis. Chapter 2 describes a method for the diastereoselective synthesis of substituted tetrahydro-thiophenes and -thiopyrans via thia-Prins cyclization reaction. Chapter 3 deals with the diastereoselective synthesis of substituted morpholines from N-tethered alkenols and its application in total synthesis of (±)-chelonin A. In chapter 4, FeCl3-mediated carbenium-ion induced intramolecular cyclization of N-tethered alkyne-benzyl alkanols is described. Chapter 5 presents the synthesis of tetrahydroisoquinolines from N-tethered aryl-benzyl alkanols mediated by BF3.OEt2
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Supervisor: Anil Kumar Saikia
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CHEMISTRY
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