Studies on calcium signaling genes phospholipase C-1, secretory phospholipase A2, and calcium proton exchanger-1 in Neurospora crassa

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dc.contributor.authorBarman, Ananya
dc.date.accessioned2018-02-12T07:36:20Z
dc.date.accessioned2023-10-19T11:07:23Z
dc.date.available2018-02-12T07:36:20Z
dc.date.available2023-10-19T11:07:23Z
dc.date.issued2017
dc.descriptionSupervisors: Ranjan Tamuli and Utpal Boraen_US
dc.description.abstractThe universal second messenger Ca2+ plays a central role in intracellular signaling in eukaryotes. Neurospora crassa is a naturally occurring filamentous fungus extensively used as a model organism to understand different aspects of biological processes including the Ca2+ signaling machinery. However, only a few Ca2+ signaling genes have been studied so far in N. crassa and detailed knowledge about its Ca2+ signaling components has remained largely unknown. Therefore, in my Ph.D thesis work, I have studied the cellular roles of three important Ca2+ signaling genes phospholipase C-1 (plc-1), secretory phospholipase A2 (sPLA2), and calcium proton exchanger-1 (cpe-1) in N. crassa. I found that the plc-1, splA2, and cpe-1 genes are involved in the regulation of [Ca2+]c, carotenoid accumulation, survival under stress conditions, and acquisition of induced thermotolerance in N. crassa. Studies on the double mutants of plc-1, splA2, and cpe-1 revealed that they synthetically regulate growth, aerial hyphae, biomass accumulation, conidial germination, carotenoid accumulation, fertility, Ca2+ stress tolerance, UV survival, oxidative stress survival, and acquisition of thermotolerance induced by heat shock. I have shown that the signaling functions of the plc-1, splA2, and cpe-1 genes are independent of cAMP mechanism.en_US
dc.identifier.otherROLL NO. 11610630
dc.identifier.urihttps://gyan.iitg.ac.in/handle/123456789/899
dc.language.isoenen_US
dc.relation.ispartofseriesTH-1649;
dc.subjectBIOSCIENCES AND BIOENGINEERINGen_US
dc.titleStudies on calcium signaling genes phospholipase C-1, secretory phospholipase A2, and calcium proton exchanger-1 in Neurospora crassaen_US
dc.typeThesisen_US
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