Studies Toward the Reactivity of Hydrazones for the Synthesis of Functionalized Pyrazoles and Nitromethyl Sulfones and the Application of Pyrazoles Thereof

Abstract

The thesis contains four chapters. The first chapter focuses on synthesis of bisarylnitromethyl sulfones via iron-mediated radical nitration of bisarylsulfonylhydrazones followed by elimination of N2. The second chapter deals with vanadium catalyzed C-N bond formation of alkenyl hydrazones via dehydrogenative cross-coupling for the synthesis of highly substituted pyrazoles. The third chapter contains 2,2,6,6-tetramethylpiperi-dine-1-oxyl (TEMPO)/N-bromosuccinimide (NBS) mediated C-H oxidative cyclization of vinylhydrazones for the synthesis of functionalized pyrazoles. The fourth chapter describes UV-visible and fluorescence photophysical properties of some of the synthesized pyrazoles and interaction of two of the pyrazole compounds with BSA