(The) Drug Binding Pathways and Conformational Deviations of G-quadruplex DNA under Different Chemical and Thermal Conditions: A Computational Study

Simple item page
dc.contributor.authorPal, Saikat
dc.date.accessioned2021-11-23T11:56:25Z
dc.date.accessioned2023-10-19T12:11:37Z
dc.date.available2021-11-23T11:56:25Z
dc.date.available2023-10-19T12:11:37Z
dc.date.issued2021
dc.descriptionSupervisor: Sandip Paulen_US
dc.description.abstractNucleic acid sequences containing series of guanine can form G-quadruplex structures, which are of special interest because of their high thermal stability, resistance to denaturing conditions, and stiffness. Moreover, due to the diverse and polymeric nature, it draws the attention of the scientific world in significant and diverse fields. Chapter 1 introduces the formation and stability of the G-quadruplex DNA in different chemical and thermal conditions along with its applications through literature survey. In Chapter 2, we have reported about the conformational changes of the thrombin-binding G-quadruplex aptamer (TBA) under dissimilar SrCl2 salt concentrations. Chapter 3 deals with the conformational changes of the human telomeric G-quadruplex DNA at varying KCl salt concentrations and temperatures under non-polar and polar confinements. In Chapter 4, we have discussed about the effect of hydrated and non-hydrated choline chloride-urea deep eutectic solvent (namely reline) on TBA G-quadruplex DNA. Chapter 5 describes the role of reline, a natural DES, on temperature induced conformational changes of c-KIT G-quadruplex DNA. In Chapter 6, we have investigated the binding modes and pathway of APTO-253 on c-KIT G-quadruplex DNA. In the last chapter i.e., Chapter 7 we have summarized the overall findings to reflect upon the interpretation about the conformational deviation of the different types of G-quadruplex DNAs under different chemical and thermal conditions and its drug binding pathway.en_US
dc.identifier.otherROLL NO.156122030
dc.identifier.urihttps://gyan.iitg.ac.in/handle/123456789/1965
dc.language.isoenen_US
dc.relation.ispartofseriesTH-2517;
dc.subjectCHEMISTRYen_US
dc.title(The) Drug Binding Pathways and Conformational Deviations of G-quadruplex DNA under Different Chemical and Thermal Conditions: A Computational Studyen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
Abstract-TH-2517_156122030.pdf
Size:
107.99 KB
Format:
Adobe Portable Document Format
Description:
ABSTRACT
Download
No Thumbnail Available
Name:
TH-2517_156122030.pdf
Size:
48.58 MB
Format:
Adobe Portable Document Format
Description:
THESIS
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download
Collections
PhD Theses (Chemistry)