Transition-Metal-Catalyzed Auxiliary Assisted Site-Selective C-H Functionalization: Access to Functionalized N-Heterocycles

Abstract

The thesis is comprised of four chapters. The first chapter describes a general introduction of the auxiliary assisted regioselective C-H functionalization of N-heterocycles under transition-metal (TM) catalysis. The second chapter demonstrates a Pd-catalyzed C4-H arylation of indoles utilizing simple arenes via 2-fold C-H activation/C-C coupling. The third chapter deals with merging C-H/C-C activation for the C4-H allylation of indoles with vinylcyclopropanes under redox-neutral Ru-catalysis. The fourth chapter illustrates a cascade C-H functionalization/2-fold annulation of 2-aryloxazolines with 1,2,3-triazoles to afford heteroaryl-tethered oxazoloisoquinolinones under Rh-catalysis.