Design, synthesis and studies on the photophysical properties of unnatural c-triazolyl, aryl fused n-triazolyl nucleosides and hybridisation accompayning fret event in another set of chimeric dna duplexes

dc.contributor.authorDas, Suman Kalyan
dc.date.accessioned2017-12-11T06:32:10Z
dc.date.accessioned2023-10-19T12:09:29Z
dc.date.available2017-12-11T06:32:10Z
dc.date.available2023-10-19T12:09:29Z
dc.date.issued2017
dc.descriptionSupervisor: Subhendu Sekhar Bagen_US
dc.description.abstractIn short Chapter 1 is a review on the synthesis of unnatural C-nucleosides. Chapter 2 deals with the cobalt catalyzed conversion of 1'-α-ethynyl sugar to 1'-β-ethynyl sugar followed by the synthesis of C-triazolyl-β-nucleosides cTBDo/Ac and their photophysical study. In Chapter 3, the synthesis of an angularly expanded compact hydrophobic Fused triazolyl phenanthrene unnatural nucleoside FTPhen and its photophysical properties are described. In addition, its DNA duplex stabilization within a trimeric DNA duplex against all the natural nucleobases was explored theoretically. Chapter 4 explains the synthesis of an angularly expanded fused triaozalyl nucleoside FTQuon which retains a donor and an acceptor face to make hydrogen bonds with cytosine and thymine. Theoretical calculation suggested that this angularly expanded fused triazolyl nucleoside can act as a complementary nucleoside against cytosine and thymine. Chapter 5 illustrates FRET event within a chimeric DNA duplex involving triazolyl phenanthrene labelled unnatural nucleoside TPhenBDo as a FRET donor and oxopyrene OxoPyU or perylene PerU labelled natural nucleoside as a FRET acceptor.en_US
dc.identifier.otherROLL No. 11612228
dc.identifier.urihttps://gyan.iitg.ac.in/handle/123456789/885
dc.language.isoenen_US
dc.relation.ispartofseriesTH-1635;
dc.subjectCHEMISTRYen_US
dc.titleDesign, synthesis and studies on the photophysical properties of unnatural c-triazolyl, aryl fused n-triazolyl nucleosides and hybridisation accompayning fret event in another set of chimeric dna duplexesen_US
dc.typeThesisen_US
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