Synthesis of complex nitrogen heterocyclic compounds
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Date
2017
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Abstract
The contents of this thesis have been divided into five chapters based on the results of experimental work performed during the complete course of the research period. The chapter 1 mainly discusses about synthetic strategy and utility of propargylamines. Chapter 2 describes regioselective one-pot, three-component synthesis of substituted 2H-indazoles from 2-nitroarylaldehyde, alkyne and amine catalyzed by CuBr/Zn(OTf)2 system. Chapter 3 illustrates Ag(OTf) catalyzed synthesis of substituted pyrazole N-oxides and pyrazoles from propargylamines. Chapter 4 demonstrates synthesis of highly substituted 4-iodopyrazole Noxides and pyrazoles from propargylamines. Chapter 5 explains that, a facile synthesis of benzo[1,4]oxazepine fused tetrahydroisoquinoline and tetrahydro-β-carboline analogues via Pictet-Spengler reaction of intramolecular cyclic iminium ion intermediates. Each chapter constitute four sections, describing introduction, present work, experimental work and spectral data, respectively.
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Supervisor: Anil K Saikia
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CHEMISTRY