Transition-Metal-Catalyzed Weak Chelating N-Oxide Directed C-H Functionalization of Quinolines

Abstract

The thesis is organized into four chapters. The initial chapter delineates a detailed analysis on C-H functionalization for the modification of quinoline under transition-metal-catalysis. The second chapter deals with C8-allylation of quinoline N-oxides (QNOs) using vinylcyclopropanes (VCPs) as allyl source under Rh-catalysis. The third chapter demonstrates a Co(III)-catalyzed site-selective C8-alkylation of quinolines N-oxides using cyclopropanols (Cyp) as the alkylating agent via C-H/C-C bond activation. The fourth chapter focuses on Pd(II)-catalyzed relay C-H activation of 8-methylquinoline N-oxides with maleimides resulted dual C(sp3)–H/C7(sp2)–H activation and annulation.